Enhancement of antitumor immunity by combination of anti-CTLA-4 antibody and radioimmunotherapy through the suppression of Tregs

Cytotoxic T lymphocyte antigen-4 (CTLA-4) is expressed during cluster of differentiation (CD)4+ T-cell activation and terminates immune responses by interrupting CD28-enhanced activation. In addition, CTLA-4 is known to be constitutively expressed in regulatory T-cells (Tregs) and to contribute to i...

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Publicado no:Oncol Lett
Main Authors: Son, Cheol-Hun, Bae, Jaeho, Lee, Hong-Rae, Yang, Kwangmo, Park, You-Soo
Formato: Artigo
Idioma:Inglês
Publicado em: D.A. Spandidos 2017
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5431413/
https://ncbi.nlm.nih.gov/pubmed/28521478
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/ol.2017.5933
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