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Generation of mutation hotspots in ageing bacterial colonies

How do ageing bacterial colonies generate adaptive mutants? Over a period of two months, we isolated on ageing colonies outgrowing mutants able to use a new carbon source, and sequenced their genomes. This allowed us to uncover exquisite details on the molecular mechanism behind their adaptation: mo...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Sekowska, Agnieszka, Wendel, Sofie, Fischer, Emil C., Nørholm, Morten H. H., Danchin, Antoine
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2016
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5431349/
https://ncbi.nlm.nih.gov/pubmed/28442761
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-016-0005-4
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