Immune-checkpoint protein VISTA critically regulates the IL-23/IL-17 inflammatory axis

V-domain Immunoglobulin Suppressor of T cell Activation (VISTA) is an inhibitory immune-checkpoint molecule that suppresses CD4(+) and CD8(+) T cell activation when expressed on antigen-presenting cells. Vsir(−/−) mice developed loss of peripheral tolerance and multi-organ chronic inflammatory pheno...

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Publicado no:Sci Rep
Main Authors: Li, Na, Xu, Wenwen, Yuan, Ying, Ayithan, Natarajan, Imai, Yasutomo, Wu, Xuesong, Miller, Halli, Olson, Michael, Feng, Yunfeng, Huang, Yina H., Jo Turk, Mary, Hwang, Samuel T., Malarkannan, Subramaniam, Wang, Li
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5431161/
https://ncbi.nlm.nih.gov/pubmed/28469254
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-01411-1
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