High Fat Diet-Induced Hepatic 18-Carbon Fatty Acids Accumulation Up-Regulates CYP2A5/CYP2A6 via NF-E2-Related Factor 2

To investigate the role of hepatic 18-carbon fatty acids (FA) accumulation in regulating CYP2A5/2A6 and the significance of Nrf2 in the process during hepatocytes steatosis, Nrf2-null, and wild type mice fed with high-fat diet (HFD), and Nrf2 silenced or over expressed HepG2 cells administered with...

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Detalhes bibliográficos
Publicado no:Front Pharmacol
Main Authors: Wang, Xing-he, Cui, Xiao-xu, Sun, Xiao-qi, Wang, Xing-hui, Li, Xiao-chong, Qi, Yue, Li, Wei, Han, Mei-yu, Muhammad, Ishfaq, Zhang, Xiu-ying
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2017
Assuntos:
Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5431014/
https://ncbi.nlm.nih.gov/pubmed/28555106
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2017.00233
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