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Cation and voltage dependence of lidocaine inhibition of the hyperpolarization-activated cyclic nucleotide-gated HCN1 channel
Lidocaine is known to inhibit the hyperpolarization-activated mixed cation current (I(h)) in cardiac myocytes and neurons, as well in cells transfected with cloned Hyperpolarization-activated Cyclic Nucleotide-gated (HCN) channels. However, the molecular mechanism of I(h) inhibition by this drug has...
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| Veröffentlicht in: | Sci Rep |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Nature Publishing Group UK
2017
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5430837/ https://ncbi.nlm.nih.gov/pubmed/28455536 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-01253-x |
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