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NKG2D(+)CD4(+) T Cells Kill Regulatory T Cells in a NKG2D-NKG2D Ligand- Dependent Manner in Systemic Lupus Erythematosus

Systemic lupus erythematosus (SLE) features a decreased pool of CD4(+)CD25(+)Foxp3(+) T regulatory (Treg) cells. We had previously observed NKG2D(+)CD4(+) T cell expansion in contrast to a decreased pool of Treg cells in SLE patients, but whether NKG2D(+)CD4(+) T cells contribute to the decreased Tr...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Yang, Di, Tian, Zhiqiang, Zhang, Mengjie, Yang, Weibing, Tang, Jun, Wu, Yuzhang, Ni, Bing
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5430709/
https://ncbi.nlm.nih.gov/pubmed/28455530
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-01379-y
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