Mechanisms underlying cognitive deficits in a mouse model for Costello Syndrome are distinct from other RASopathy mouse models

RASopathies, characterized by germline mutations in genes encoding proteins of the RAS-ERK signaling pathway, show overlapping phenotypes, which manifest themselves with a varying severity of intellectual disability. However, it is unclear to what extent they share the same downstream pathophysiolog...

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Vydáno v:Sci Rep
Hlavní autoři: Schreiber, Jadwiga, Grimbergen, Laura-Anne, Overwater, Iris, Vaart, Thijs van der, Stedehouder, Jeffrey, Schuhmacher, Alberto J., Guerra, Carmen, Kushner, Steven A., Jaarsma, Dick, Elgersma, Ype
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2017
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5430680/
https://ncbi.nlm.nih.gov/pubmed/28455524
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-01218-0
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