The centrosomal OFD1 protein interacts with the translation machinery and regulates the synthesis of specific targets

Protein synthesis is traditionally associated with specific cytoplasmic compartments. We now show that OFD1, a centrosomal/basal body protein, interacts with components of the Preinitiation complex of translation (PIC) and of the eukaryotic Initiation Factor (eIF)4F complex and modulates the transla...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Iaconis, Daniela, Monti, Maria, Renda, Mario, van Koppen, Arianne, Tammaro, Roberta, Chiaravalli, Marco, Cozzolino, Flora, Pignata, Paola, Crina, Claudia, Pucci, Piero, Boletta, Alessandra, Belcastro, Vincenzo, Giles, Rachel H., Surace, Enrico Maria, Gallo, Simone, Pende, Mario, Franco, Brunella
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5430665/
https://ncbi.nlm.nih.gov/pubmed/28450740
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-01156-x
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