Obestatin stimulates glucose-induced insulin secretion through ghrelin receptor GHS-R

Orexigenic hormone ghrelin and anorexic hormone obestatin are encoded by the same preproghrelin gene. While it is known that ghrelin inhibits glucose-stimulated insulin secretion (GSIS), the effect of obestatin on GSIS is unclear. Ghrelin’s effect is mediated by its receptor Growth Hormone Secretago...

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Pubblicato in:Sci Rep
Autori principali: Pradhan, Geetali, Wu, Chia-Shan, Han Lee, Jong, Kanikarla, Preeti, Guo, Shaodong, Yechoor, Vijay K., Samson, Susan L., Sun, Yuxiang
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5430520/
https://ncbi.nlm.nih.gov/pubmed/28428639
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-00888-0
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