Similarity- and Substructure-Based Development of β(2)-Adrenergic Receptor Ligands Based on Unusual Scaffolds

[Image: see text] The β(2)-adrenergic receptor (β(2)AR) is a G protein-coupled receptor (GPCR) and a well-explored target. Here, we report the discovery of 13 ligands, ten of which are novel, of this particular GPCR. They have been identified by similarity- and substructure-based searches using mult...

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Udgivet i:ACS Med Chem Lett
Main Authors: Schmidt, Denis, Gunera, Jakub, Baker, Jillian G., Kolb, Peter
Format: Artigo
Sprog:Inglês
Udgivet: American Chemical Society 2017
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5430404/
https://ncbi.nlm.nih.gov/pubmed/28523097
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.6b00363
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