A Pair of Maternal Chromosomes Derived from Meiotic Nondisjunction in Trisomy 21 Affects Nuclear Architecture and Transcriptional Regulation

Eukaryotic genomes are organised into complex higher-order structures within the nucleus, and the three-dimensional arrangement of chromosomes is functionally important for global gene regulation. The existence of supernumerary chromosome 21 in Down syndrome may perturb the nuclear architecture at d...

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Gepubliceerd in:Sci Rep
Hoofdauteurs: Omori, Sayaka, Tanabe, Hideyuki, Banno, Kimihiko, Tsuji, Ayumi, Nawa, Nobutoshi, Hirata, Katsuya, Kawatani, Keiji, Kokubu, Chikara, Takeda, Junji, Taniguchi, Hidetoshi, Arahori, Hitomi, Wada, Kazuko, Kitabatake, Yasuji, Ozono, Keiichi
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group UK 2017
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5429678/
https://ncbi.nlm.nih.gov/pubmed/28396582
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-00714-7
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