Anti‐inflammatory and analgesic activity of carnosol and carnosic acid in vivo and in vitro and in silico analysis of their target interactions

BACKGROUND AND PURPOSE: The diterpenoids carnosol (CS) and carnosic acid (CA) from Salvia spp. exert prominent anti‐inflammatory activities but their molecular mechanisms remained unclear. Here we investigated the effectiveness of CS and CA in inflammatory pain and the cellular interference with the...

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Detalhes bibliográficos
Publicado no:Br J Pharmacol
Main Authors: Maione, Francesco, Cantone, Vincenza, Pace, Simona, Chini, Maria Giovanna, Bisio, Angela, Romussi, Giovanni, Pieretti, Stefano, Werz, Oliver, Koeberle, Andreas, Mascolo, Nicola, Bifulco, Giuseppe
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2016
Assuntos:
Themed Section: Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5429324/
https://ncbi.nlm.nih.gov/pubmed/27464306
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.13545
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