Design of polyaspartic acid peptide-poly (ethylene glycol)-poly (ε-caprolactone) nanoparticles as a carrier of hydrophobic drugs targeting cancer metastasized to bone

Treatment of cancer metastasized to bone is still a challenge due to hydrophobicity, instability, and lack of target specificity of anticancer drugs. Poly (ethylene glycol)-poly (ε-caprolactone) polymer (PEG-PCL) is an effective, biodegradable, and biocompatible hydrophobic drug carrier, but lacks b...

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Опубликовано в: :Int J Nanomedicine
Главные авторы: Liu, Jinsong, Zeng, Youyun, Shi, Shuai, Xu, Lihua, Zhang, Hualin, Pathak, Janak L, Pan, Yihuai
Формат: Artigo
Язык:Inglês
Опубликовано: Dove Medical Press 2017
Предметы:
Original Research
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5428813/
https://ncbi.nlm.nih.gov/pubmed/28507436
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/IJN.S133787
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