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TIMP-1 is upregulated, but not essential in hepatic fibrogenesis and carcinogenesis in mice
Tissue inhibitor of metalloproteinases-1 (TIMP-1) is upregulated during hepatic fibrogenesis and considered to promote fibrosis in the injured liver by inhibition of matrix metalloproteases (MMP) and degradation of extracellular matrix. Moreover, TIMP-1 displays anti-apoptotic properties, in patient...
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Publié dans: | Sci Rep |
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Auteurs principaux: | , , , , , , |
Format: | Artigo |
Langue: | Inglês |
Publié: |
Nature Publishing Group UK
2017
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Sujets: | |
Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5428806/ https://ncbi.nlm.nih.gov/pubmed/28386095 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-00671-1 |
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