Crebbp loss cooperates with Bcl2 overexpression to promote lymphoma in mice

CREBBP is targeted by inactivating mutations in follicular lymphoma (FL) and diffuse large B-cell lymphoma (DLBCL). Here, we provide evidence from transgenic mouse models that Crebbp deletion results in deficits in B-cell development and can cooperate with Bcl2 overexpression to promote B-cell lymph...

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Vydáno v:Blood
Hlavní autoři: García-Ramírez, Idoia, Tadros, Saber, González-Herrero, Inés, Martín-Lorenzo, Alberto, Rodríguez-Hernández, Guillermo, Moore, Dalia, Ruiz-Roca, Lucía, Blanco, Oscar, Alonso-López, Diego, Rivas, Javier De Las, Hartert, Keenan, Duval, Romain, Klinkebiel, David, Bast, Martin, Vose, Julie, Lunning, Matthew, Fu, Kai, Greiner, Timothy, Rodrigues-Lima, Fernando, Jiménez, Rafael, Criado, Francisco Javier García, Cenador, María Begoña García, Brindle, Paul, Vicente-Dueñas, Carolina, Alizadeh, Ash, Sánchez-García, Isidro, Green, Michael R.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Hematology 2017
Témata:
Lymphoid Neoplasia
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5428458/
https://ncbi.nlm.nih.gov/pubmed/28288979
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2016-08-733469
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