Loss of p53 exacerbates multiple myeloma phenotype by facilitating the reprogramming of hematopoietic stem/progenitor cells to malignant plasma cells by MafB

Multiple myeloma (MM) is a serious, mostly incurable human cancer of malignant plasma cells. Chromosomal translocations affecting MAFB are present in a significant percentage of multiple myeloma patients. Genetically engineered Sca1-MafB mice, in which MafB expression is limited to hematopoietic ste...

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Detalhes bibliográficos
Main Authors: Vicente-Dueñas, Carolina, González-Herrero, Inés, Cenador, María Begoña García, Criado, Francisco Javier García, Sánchez-García, Isidro
Formato: Artigo
Idioma:Inglês
Publicado em: Landes Bioscience 2012
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3495831/
https://ncbi.nlm.nih.gov/pubmed/22983007
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.22186
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