Ror2 signaling regulates Golgi structure and transport through IFT20 for tumor invasiveness

Signaling through the Ror2 receptor tyrosine kinase promotes invadopodia formation for tumor invasion. Here, we identify intraflagellar transport 20 (IFT20) as a new target of this signaling in tumors that lack primary cilia, and find that IFT20 mediates the ability of Ror2 signaling to induce the i...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Nishita, Michiru, Park, Seung-Yeol, Nishio, Tadashi, Kamizaki, Koki, Wang, ZhiChao, Tamada, Kota, Takumi, Toru, Hashimoto, Ryuju, Otani, Hiroki, Pazour, Gregory J., Hsu, Victor W., Minami, Yasuhiro
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5428335/
https://ncbi.nlm.nih.gov/pubmed/28127051
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-016-0028-x
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