Generation of transgenic mice with elevated blood pressure by introduction of the rat renin and angiotensinogen genes.
The role of the renin-angiotensin system in blood pressure control and in the development of hypertension was investigated by generating transgenic mice carrying the rat renin or angiotensinogen gene or both genes under the control of the mouse metallothionein I promoter. The systolic blood pressure...
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| Veröffentlicht in: | Proc Natl Acad Sci U S A |
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| Hauptverfasser: | , , , , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
National Academy of Sciences
1990
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| Schlagworte: | |
| Online-Zugang: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC54280/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2195550/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.87.13.5153 |
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