Generation of transgenic mice with elevated blood pressure by introduction of the rat renin and angiotensinogen genes.

The role of the renin-angiotensin system in blood pressure control and in the development of hypertension was investigated by generating transgenic mice carrying the rat renin or angiotensinogen gene or both genes under the control of the mouse metallothionein I promoter. The systolic blood pressure...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Ohkubo, H, Kawakami, H, Kakehi, Y, Takumi, T, Arai, H, Yokota, Y, Iwai, M, Tanabe, Y, Masu, M, Hata, J
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1990
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC54280/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2195550/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.87.13.5153
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