TOP2β Is Essential for Ovarian Follicles That Are Hypersensitive to Chemotherapeutic Drugs

The mechanisms underlying chemotherapy-induced acceleration of ovarian insufficiency are not fully understood, particularly for ovarian granulosa cells (GCs). We used two widely used cancer chemotherapeutic reagents, bleomycin and VP-16, and an in vivo GC-specific DNA topoisomerase II-β (TOP2β) (Top...

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Detalhes bibliográficos
Publicado no:Mol Endocrinol
Main Authors: Zhang, Yin-Li, Yu, Chao, Ji, Shu-Yan, Li, Xiao-Meng, Zhang, Yong-Ping, Zhang, Dan, Zhou, Dawang, Fan, Heng-Yu
Formato: Artigo
Idioma:Inglês
Publicado em: Endocrine Society 2013
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5427880/
https://ncbi.nlm.nih.gov/pubmed/24002654
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/me.2013-1108
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