Flux of signalling endosomes undergoing axonal retrograde transport is encoded by presynaptic activity and TrkB

Axonal retrograde transport of signalling endosomes from the nerve terminal to the soma underpins survival. As each signalling endosome carries a quantal amount of activated receptors, we hypothesized that it is the frequency of endosomes reaching the soma that determines the scale of the trophic si...

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Détails bibliographiques
Publié dans:Nat Commun
Auteurs principaux: Wang, Tong, Martin, Sally, Nguyen, Tam H., Harper, Callista B., Gormal, Rachel S., Martínez-Mármol, Ramon, Karunanithi, Shanker, Coulson, Elizabeth J., Glass, Nick R., Cooper-White, Justin J., van Swinderen, Bruno, Meunier, Frédéric A.
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group 2016
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5427517/
https://ncbi.nlm.nih.gov/pubmed/27687129
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms12976
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