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Acute acinar pancreatitis blocks vesicle-associated membrane protein 8 (VAMP8)-dependent secretion, resulting in intracellular trypsin accumulation

Zymogen secretory granules in pancreatic acinar cells express two vesicle-associated membrane proteins (VAMP), VAMP2 and -8, each controlling 50% of stimulated secretion. Analysis of secretion kinetics identified a first phase (0–2 min) mediated by VAMP2 and second (2–10 min) and third phases (10–30...

詳細記述

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書誌詳細
出版年:J Biol Chem
主要な著者: Messenger, Scott W., Jones, Elaina K., Holthaus, Conner L., Thomas, Diana D. H., Cooley, Michelle M., Byrne, Jennifer A., Mareninova, Olga A., Gukovskaya, Anna S., Groblewski, Guy E.
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Biochemistry and Molecular Biology 2017
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5427264/
https://ncbi.nlm.nih.gov/pubmed/28242757
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.781815
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