Vesicle Associated Membrane Protein 8 (VAMP8)-mediated Zymogen Granule Exocytosis Is Dependent on Endosomal Trafficking via the Constitutive-Like Secretory Pathway

Acinar cell zymogen granules (ZG) express 2 isoforms of the vesicle-associated membrane protein family (VAMP2 and -8) thought to regulate exocytosis. Expression of tetanus toxin to cleave VAMP2 in VAMP8 knock-out (−/−) acini confirmed that VAMP2 and -8 are the primary VAMPs for regulated exocytosis,...

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Autori principali: Messenger, Scott W, Falkowski, Michelle A., Thomas, Diana D. H., Jones, Elaina K., Hong, Wanjin, Giasano, Herbert Y., Boulis, Nicholas M., Groblewski, Guy E.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2014
Soggetti:
Cell Biology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4183833/
https://ncbi.nlm.nih.gov/pubmed/25138214
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.593913
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