Threonine eliminylation by bacterial phosphothreonine lyases rapidly causes cross-linking of mitogen-activated protein kinase (MAPK) in live cells

Old long-lived proteins contain dehydroalanine (Dha) and dehydrobutyrine (Dhb), two amino acids engendered by dehydration of serines and threonines, respectively. Although these residues have a suspected role in protein cross-linking and aggregation, their direct implication has yet to be determined...

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Veröffentlicht in:J Biol Chem
Hauptverfasser: Meijer, Benoit M., Jang, Suk Min, Guerrera, Ida C., Chhuon, Cerina, Lipecka, Joanna, Reisacher, Caroline, Baleux, Françoise, Sansonetti, Philippe J., Muchardt, Christian, Arbibe, Laurence
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2017
Schlagworte:
Genomics and Proteomics
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5427260/
https://ncbi.nlm.nih.gov/pubmed/28325837
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.775940
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