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Human pluripotent stem cells recurrently acquire and expand dominant negative P53 mutations
Human pluripotent stem cells (hPSCs) can self-renew indefinitely, making them an attractive source for regenerative therapies. This expansion potential has been linked with acquisition of large copy number variants (CNVs) that provide mutant cells with a growth advantage in culture1–3. However, the...
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| הוצא לאור ב: | Nature |
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| Main Authors: | , , , , , , , , , , , , , , , , |
| פורמט: | Artigo |
| שפה: | Inglês |
| יצא לאור: |
2017
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| נושאים: | |
| גישה מקוונת: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5427175/ https://ncbi.nlm.nih.gov/pubmed/28445466 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature22312 |
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