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Osteopontin inhibits osteoblast responsiveness through the down-regulation of focal adhesion kinase mediated by the induction of low–molecular weight protein tyrosine phosphatase

Osteopontin (OPN) is an osteogenic marker protein. Osteoblast functions are affected by inflammatory cytokines and pathological conditions. OPN is highly expressed in bone lesions such as those in rheumatoid arthritis. However, local regulatory effects of OPN on osteoblasts remain ambiguous. Here we...

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Библиографические подробности
Опубликовано в: :Mol Biol Cell
Главные авторы: Kusuyama, Joji, Bandow, Kenjiro, Ohnishi, Tomokazu, Hisadome, Mitsuhiro, Shima, Kaori, Semba, Ichiro, Matsuguchi, Tetsuya
Формат: Artigo
Язык:Inglês
Опубликовано: The American Society for Cell Biology 2017
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5426847/
https://ncbi.nlm.nih.gov/pubmed/28331074
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E16-10-0716
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