Osteopontin inhibits osteoblast responsiveness through the down-regulation of focal adhesion kinase mediated by the induction of low–molecular weight protein tyrosine phosphatase

Osteopontin (OPN) is an osteogenic marker protein. Osteoblast functions are affected by inflammatory cytokines and pathological conditions. OPN is highly expressed in bone lesions such as those in rheumatoid arthritis. However, local regulatory effects of OPN on osteoblasts remain ambiguous. Here we...

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Xehetasun bibliografikoak
Argitaratua izan da:Mol Biol Cell
Egile Nagusiak: Kusuyama, Joji, Bandow, Kenjiro, Ohnishi, Tomokazu, Hisadome, Mitsuhiro, Shima, Kaori, Semba, Ichiro, Matsuguchi, Tetsuya
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: The American Society for Cell Biology 2017
Gaiak:
Articles
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5426847/
https://ncbi.nlm.nih.gov/pubmed/28331074
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E16-10-0716
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