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Expression of a mutated bovine growth hormone gene suppresses growth of transgenic mice.

To determine the importance of the third alpha-helix in bovine growth hormone (bGH) relative to growth-related biological activities, the following experimental approach was used: (i) mutagenesis of helix III of bGH to generate an idealized amphiphilic helix; (ii) in vitro expression analyses of the...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Chen, W Y, Wight, D C, Wagner, T E, Kopchick, J J
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1990
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC54261/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2367524/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.87.13.5061
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