Cell Cycle-Targeting MicroRNAs as Therapeutic Tools Against Refractory Cancers

Cyclins and cyclin-dependent kinases (CDKs) are hyperactivated in numerous tumors. To identify means of interfering with cyclins/CDKs, we performed nine genome-wide screens for human microRNAs (miRNAs) directly regulating cell cycle proteins. We uncovered a distinct class of miRNAs that target nearl...

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Pubblicato in:Cancer Cell
Autori principali: Hydbring, Per, Wang, Yinan, Fassl, Anne, Li, Xiaoting, Matia, Veronica, Otto, Tobias, Choi, Yoon Jong, Sweeney, Katharine E., Suski, Jan M., Yin, Hao, Bogorad, Roman L., Goel, Shom, Yuzugullu, Haluk, Kauffman, Kevin, Yang, Junghoon, Jin, Chong, Li, Yingxiang, Floris, Davide, Swanson, Richard, Ng, Kimmie, Sicinska, Ewa, Anders, Lars, Zhao, Jean J., Polyak, Kornelia, Anderson, Daniel G., Li, Cheng, Sicinski, Piotr
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5425285/
https://ncbi.nlm.nih.gov/pubmed/28399412
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2017.03.004
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