MicroRNA-181a-mediated downregulation of AC9 protein decreases intracellular cAMP level and inhibits ATRA-induced APL cell differentiation

AC9 is one of the adenylate cyclase (AC) isoforms, which catalyze the conversion of ATP to cAMP, an important second messenger. We previously found that the integration of cAMP/PKA pathway with nuclear receptor-mediated signaling was required during all-trans retinoic acid (ATRA)-induced maturation...

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Publicado en:Cell Death Dis
Autores principales: Zhuang, L K, Xu, G P, Pan, X R, Lou, Y J, Zou, Q P, Xia, D, Yan, W W, Zhang, Y T, Jia, P M, Tong, J H
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group 2014
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Original Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5424108/
https://ncbi.nlm.nih.gov/pubmed/24722286
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2014.130
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