Mutation of a Nopp140 gene dao-5 alters rDNA transcription and increases germ cell apoptosis in C. elegans

Human diseases of impaired ribosome biogenesis resulting from disruption of rRNA biosynthesis or loss of ribosomal components are collectively described as ‘ribosomopathies'. Treacher Collins syndrome (TCS), a representative human ribosomopathy with craniofacial abnormalities, is attributed to...

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Detalhes bibliográficos
Publicado no:Cell Death Dis
Main Authors: Lee, C-C, Tsai, Y-T, Kao, C-W, Lee, L-W, Lai, H-J, Ma, T-H, Chang, Y-S, Yeh, N-H, Lo, S J
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2014
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5424100/
https://ncbi.nlm.nih.gov/pubmed/24722283
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2014.114
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