Nimbolide targets BCL2 and induces apoptosis in preclinical models of Waldenströms macroglobulinemia

Neem leaf extract (NLE) has medicinal properties, which have been attributed to its limonoid content. We identified the NLE tetranorterpenoid, nimbolide, as being the key limonoid responsible for the cytotoxicity of NLE in various preclinical models of human B-lymphocyte cancer. Of the models tested...

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Bibliografiske detaljer
Udgivet i:Blood Cancer J
Main Authors: Chitta, K, Paulus, A, Caulfield, T R, Akhtar, S, Blake, M-KK, Ailawadhi, S, Knight, J, Heckman, M G, Pinkerton, A, Chanan-Khan, A
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2014
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Original Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5424099/
https://ncbi.nlm.nih.gov/pubmed/25382610
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bcj.2014.74
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