Nimbolide targets BCL2 and induces apoptosis in preclinical models of Waldenströms macroglobulinemia

Neem leaf extract (NLE) has medicinal properties, which have been attributed to its limonoid content. We identified the NLE tetranorterpenoid, nimbolide, as being the key limonoid responsible for the cytotoxicity of NLE in various preclinical models of human B-lymphocyte cancer. Of the models tested...

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Detalhes bibliográficos
Publicado no:Blood Cancer J
Main Authors: Chitta, K, Paulus, A, Caulfield, T R, Akhtar, S, Blake, M-KK, Ailawadhi, S, Knight, J, Heckman, M G, Pinkerton, A, Chanan-Khan, A
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2014
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5424099/
https://ncbi.nlm.nih.gov/pubmed/25382610
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bcj.2014.74
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