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Microbiota induces tonic CCL2 systemic levels that control pDC trafficking in steady state

Plasmacytoid dendritic cells (pDCs) detect viruses initiating antiviral IFN-I responses. The microbiota is known to shape immune responses, but whether it influences pDC homeostasis and/or function is poorly understood. By comparing pDCs in germ-free and specific pathogen-free mice, we found that th...

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Detalhes bibliográficos
Publicado no:Mucosal Immunol
Main Authors: Swiecki, Melissa, Miller, Hannah, Sesti-Costa, Renata, Cella, Marina, Gilfillan, Susan, Colonna, Marco
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5423869/
https://ncbi.nlm.nih.gov/pubmed/27827374
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mi.2016.99
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