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Introducing COCOS: codon consequence scanner for annotating reading frame changes induced by stop-lost and frame shift variants

SUMMARY: Reading frame altering genomic variants can impact gene expression levels and the structure of protein products, thus potentially inducing disease phenotypes. Current annotation approaches report the impact of such variants in the context of altered DNA sequence only; attributes of the resu...

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Bibliographic Details
Published in:Bioinformatics
Main Authors: Butkiewicz, Mariusz, Haines, Jonathan L, Bush, William S
Format: Artigo
Language:Inglês
Published: Oxford University Press 2017
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5423451/
https://ncbi.nlm.nih.gov/pubmed/28122779
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/bioinformatics/btw820
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