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PU.1 supports TRAIL-induced cell death by inhibiting NF-κB-mediated cell survival and inducing DR5 expression
The hematopoietic Ets-domain transcription factor PU.1/SPI1 orchestrates myeloid, B- and T-cell development, and also supports hematopoietic stem cell maintenance. Although PU.1 is a renowned tumor suppressor in acute myeloid leukemia (AML), a disease characterized by an accumulation of immature bla...
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出版年: | Cell Death Differ |
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主要な著者: | , , , , , , , , |
フォーマット: | Artigo |
言語: | Inglês |
出版事項: |
Nature Publishing Group
2017
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主題: | |
オンライン・アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5423115/ https://ncbi.nlm.nih.gov/pubmed/28362429 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2017.40 |
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