PU.1 supports TRAIL-induced cell death by inhibiting NF-κB-mediated cell survival and inducing DR5 expression

The hematopoietic Ets-domain transcription factor PU.1/SPI1 orchestrates myeloid, B- and T-cell development, and also supports hematopoietic stem cell maintenance. Although PU.1 is a renowned tumor suppressor in acute myeloid leukemia (AML), a disease characterized by an accumulation of immature bla...

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Detalhes bibliográficos
Publicado no:Cell Death Differ
Main Authors: Haimovici, Aladin, Humbert, Magali, Federzoni, Elena A, Shan-Krauer, Deborah, Brunner, Thomas, Frese, Steffen, Kaufmann, Thomas, Torbett, Bruce E, Tschan, Mario P
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
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Original Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5423115/
https://ncbi.nlm.nih.gov/pubmed/28362429
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2017.40
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