The ErbB3 receptor tyrosine kinase negatively regulates Paneth cells by PI3K-dependent suppression of Atoh1

Paneth cells (PCs), a secretory population located at the base of the intestinal crypt, support the intestinal stem cells (ISC) with growth factors and participate in innate immunity by releasing antimicrobial peptides, including lysozyme and defensins. PC dysfunction is associated with disorders su...

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Bibliografiske detaljer
Udgivet i:Cell Death Differ
Main Authors: Almohazey, Dana, Lo, Yuan-Hung, Vossler, Claire V, Simmons, Alan J, Hsieh, Jonathan J, Bucar, Edie B, Schumacher, Michael A, Hamilton, Kathryn E, Lau, Ken S, Shroyer, Noah F, Frey, Mark R
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2017
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Original Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5423110/
https://ncbi.nlm.nih.gov/pubmed/28304405
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2017.27
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