Elimination of murine and human T-cell epitopes in recombinant immunotoxin eliminates neutralizing and anti-drug antibodies in vivo

Antibodies against the toxin portion of recombinant immunotoxins (RIT) reduce their efficacy and pose a potential safety risk. To overcome this problem we mutated the very immunogenic immunotoxin SS1P to produce LMB-T20, a de-immunized RIT that has the eight human T-cell epitopes in SS1P modified or...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Cell Mol Immunol
Egile Nagusiak: Mazor, Ronit, Crown, Devorah, Addissie, Selamawit, Jang, Youjin, Kaplan, Gilad, Pastan, Ira
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Nature Publishing Group 2017
Gaiak:
Research Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5423085/
https://ncbi.nlm.nih.gov/pubmed/26477977
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cmi.2015.91
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