HIF1/2α mediates hypoxia-induced LDHA expression in human pancreatic cancer cells

Glycolysis is a typical conduit for energy metabolism in pancreatic cancer (PC) due to the hypoxic microenviroment. Lactate dehydrogenase A (LDHA) catalyzes the conversion of pyruvate to lactate and is considered to be a key checkpoint of anaerobic glycolysis. The aim of the present study was to exp...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Cui, Xin-gang, Han, Zhi-tao, He, Shao-hui, Wu, Xing-da, Chen, Tian-rui, Shao, Cheng-hao, Chen, Dan-lei, Su, Ning, Chen, Yuan-ming, Wang, Ting, Wang, Jing, Song, Dian-Wen, Yan, Wang-jun, Yang, Xing-Hai, Liu, Tielong, Wei, Hai-feng, Xiao, Jianru
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2017
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5421893/
https://ncbi.nlm.nih.gov/pubmed/28193910
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.15266
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