Long-Term Exposure to Imatinib Mesylate Downregulates Hippo Pathway and Activates YAP in a Model of Chronic Myelogenous Leukemia

Despite the success of tyrosine kinase inhibitor (TKI) therapy in chronic myelogenous leukemia (CML), leukemic stem/progenitor cells remain detectable even in the state of deep molecular remission. Mechanisms that allow them to persist despite continued kinase inhibition remain unclear. We have prev...

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Detalhes bibliográficos
Publicado no:Stem Cells Dev
Main Authors: Chorzalska, Anna, Kim, Javier Flores, Roder, Karim, Tepper, Alexander, Ahsan, Nagib, Rao, R. Shyama Prasad, Olszewski, Adam J., Yu, Xiaoqing, Terentyev, Dmitry, Morgan, John, Treaba, Diana O., Zhao, Ting C., Liang, Olin, Gruppuso, Philip A., Dubielecka, Patrycja M.
Formato: Artigo
Idioma:Inglês
Publicado em: Mary Ann Liebert, Inc. 2017
Assuntos:
Original Research Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5421616/
https://ncbi.nlm.nih.gov/pubmed/28103766
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/scd.2016.0262
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