Oncostatin M drives intestinal inflammation in mice and its abundance predicts response to tumor necrosis factor-neutralizing therapy in patients with inflammatory bowel disease

Inflammatory bowel diseases (IBD), including Crohn’s disease (CD) and ulcerative colitis (UC), are complex chronic inflammatory conditions of the gastrointestinal tract that are driven by perturbed cytokine pathways. Anti-tumor necrosis factor-α (TNF) antibodies are a mainstay therapeutic approach f...

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Bibliografske podrobnosti
izdano v:Nat Med
Main Authors: West, Nathaniel R., Hegazy, Ahmed N., Owens, Benjamin M. J., Bullers, Samuel J., Linggi, Bryan, Buonocore, Sofia, Coccia, Margherita, Görtz, Dieter, This, Sébastien, Stockenhuber, Krista, Pott, Johanna, Friedrich, Matthias, Ryzhakov, Grigory, Baribaud, Frédéric, Brodmerkel, Carrie, Cieluch, Constanze, Rahman, Nahid, Müller-Newen, Gerhard, Owens, Raymond J., Kühl, Anja A., Maloy, Kevin J., Plevy, Scott E., Keshav, Satish, Travis, Simon P. L., Powrie, Fiona
Format: Artigo
Jezik:Inglês
Izdano: 2017
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5420447/
https://ncbi.nlm.nih.gov/pubmed/28368383
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.4307
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