Oncostatin M drives intestinal inflammation in mice and its abundance predicts response to tumor necrosis factor-neutralizing therapy in patients with inflammatory bowel disease

Inflammatory bowel diseases (IBD), including Crohn’s disease (CD) and ulcerative colitis (UC), are complex chronic inflammatory conditions of the gastrointestinal tract that are driven by perturbed cytokine pathways. Anti-tumor necrosis factor-α (TNF) antibodies are a mainstay therapeutic approach f...

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Publicado no:Nat Med
Main Authors: West, Nathaniel R., Hegazy, Ahmed N., Owens, Benjamin M. J., Bullers, Samuel J., Linggi, Bryan, Buonocore, Sofia, Coccia, Margherita, Görtz, Dieter, This, Sébastien, Stockenhuber, Krista, Pott, Johanna, Friedrich, Matthias, Ryzhakov, Grigory, Baribaud, Frédéric, Brodmerkel, Carrie, Cieluch, Constanze, Rahman, Nahid, Müller-Newen, Gerhard, Owens, Raymond J., Kühl, Anja A., Maloy, Kevin J., Plevy, Scott E., Keshav, Satish, Travis, Simon P. L., Powrie, Fiona
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5420447/
https://ncbi.nlm.nih.gov/pubmed/28368383
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.4307
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