Targeting BMI1(+) Cancer Stem Cells Overcomes Chemoresistance and Inhibits Metastases in Squamous Cell Carcinoma

Squamous cell carcinoma in the head and neck (HNSCC) is a common yet poorly understood cancer, with adverse clinical outcomes due to treatment resistance, recurrence, and metastasis. Putative cancer stem cells (CSCs) have been identified in HNSCC and BMI1 expression has been linked to these phenotyp...

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Detalhes bibliográficos
Publicado no:Cell Stem Cell
Main Authors: Chen, Demeng, Wu, Mansi, Li, Yang, Chang, Insoon, Quan, Yuan, Ekimyan-Salvo, Mari, Deng, Peng, Yu, Bo, Yu, Yongxin, Dong, Jiaqiang, Szymanski, John M., Ramadoss, Sivakumar, Li, Jiong, Wang, Cun-Yu
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5419860/
https://ncbi.nlm.nih.gov/pubmed/28285905
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2017.02.003
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