Histone 3.3 hotspot mutations in conventional osteosarcomas: a comprehensive clinical and molecular characterization of six H3F3A mutated cases

BACKGROUND: Histone 3.3 (H3.3) hotspot mutations in bone tumors occur in the vast majority of giant cell tumors of bone (GCTBs; 96%), chondroblastomas (95%) and in a few cases of osteosarcomas. However, clinical presentation, histopathological features, and additional molecular characteristics of H3...

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Publicat a:Clin Sarcoma Res
Autors principals: Koelsche, Christian, Schrimpf, Daniel, Tharun, Lars, Roth, Eva, Sturm, Dominik, Jones, David T. W., Renker, Eva-Kristin, Sill, Martin, Baude, Annika, Sahm, Felix, Capper, David, Bewerunge-Hudler, Melanie, Hartmann, Wolfgang, Kulozik, Andreas E., Petersen, Iver, Flucke, Uta, Schreuder, Hendrik W. B., Büttner, Reinhard, Weber, Marc-André, Schirmacher, Peter, Plass, Christoph, Pfister, Stefan M., von Deimling, Andreas, Mechtersheimer, Gunhild
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2017
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5418758/
https://ncbi.nlm.nih.gov/pubmed/28484590
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13569-017-0075-5
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