TERT promoter hotspot mutations are recurrent in myxoid liposarcomas but rare in other soft tissue sarcoma entities

BACKGROUND: Recently, recurrent point mutations in the telomerase reverse transcriptase (TERT) promoter region have been found in many human cancers, leading to a new transcription factor binding site, increased induction of TERT and subsequently to telomere maintenance. We determined the prevalence...

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Detalhes bibliográficos
Main Authors: Koelsche, Christian, Renner, Marcus, Hartmann, Wolfgang, Brandt, Regine, Lehner, Burkhard, Waldburger, Nina, Alldinger, Ingo, Schmitt, Thomas, Egerer, Gerlinde, Penzel, Roland, Wardelmann, Eva, Schirmacher, Peter, von Deimling, Andreas, Mechtersheimer, Gunhild
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2014
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4022359/
https://ncbi.nlm.nih.gov/pubmed/24726063
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1756-9966-33-33
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