The Electrogenic Na(+)/K(+) Pump Is a Key Determinant of Repolarization Abnormality Susceptibility in Human Ventricular Cardiomyocytes: A Population-Based Simulation Study

Background: Cellular repolarization abnormalities occur unpredictably due to disease and drug effects, and can occur even in cardiomyocytes that exhibit normal action potentials (AP) under control conditions. Variability in ion channel densities may explain differences in this susceptibility to repo...

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Vydáno v:Front Physiol
Hlavní autoři: Britton, Oliver J., Bueno-Orovio, Alfonso, Virág, László, Varró, András, Rodriguez, Blanca
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2017
Témata:
Physiology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5418229/
https://ncbi.nlm.nih.gov/pubmed/28529489
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphys.2017.00278
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