In Vivo and In Silico Investigation Into Mechanisms of Frequency Dependence of Repolarization Alternans in Human Ventricular Cardiomyocytes

RATIONALE: Repolarization alternans (RA) are associated with arrhythmogenesis. Animal studies have revealed potential mechanisms, but human-focused studies are needed. RA generation and frequency dependence may be determined by cell-to-cell variability in protein expression, which is regulated by ge...

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Detalhes bibliográficos
Publicado no:Circ Res
Principais autores: Zhou, Xin, Bueno-Orovio, Alfonso, Orini, Michele, Hanson, Ben, Hayward, Martin, Taggart, Peter, Lambiase, Pier D., Burrage, Kevin, Rodriguez, Blanca
Formato: Artigo
Idioma:Inglês
Publicado em: Lippincott Williams & Wilkins 2016
Assuntos:
Integrative Physiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4719495/
https://ncbi.nlm.nih.gov/pubmed/26602864
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.115.307836
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