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The noncompetitive blocker [3H]chlorpromazine labels three amino acids of the acetylcholine receptor gamma subunit: implications for the alpha-helical organization of regions MII and for the structure of the ion channel.

Labeling studies of Torpedo marmorata nicotinic acetylcholine receptor with the noncompetitive channel blocker [3H]chlorpromazine have led to the initial identification of amino acids plausibly participating to the walls of the ion channel on the alpha, beta, and delta subunits. We report here resul...

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Dades bibliogràfiques
Publicat a:Proc Natl Acad Sci U S A
Autors principals: Revah, F, Galzi, J L, Giraudat, J, Haumont, P Y, Lederer, F, Changeux, J P
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 1990
Matèries:
Accés en línia:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC54179/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1693775/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.87.12.4675
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