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Proinsulin C-Peptide Antagonizes the Profibrotic Effects of TGF-β1 via Up-Regulation of Retinoic Acid and HGF-Related Signaling Pathways

Novel signaling roles for C-peptide have recently been discovered with evidence that it can ameliorate complications of type 1 diabetes. Here we sought to identify new pathways regulated by C-peptide of relevance to the pathophysiology of diabetic nephropathy. Microarray analysis was performed to id...

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Detalhes bibliográficos
Publicado no:Mol Endocrinol
Main Authors: Hills, Claire E., Willars, Gary B., Brunskill, Nigel J.
Formato: Artigo
Idioma:Inglês
Publicado em: Endocrine Society 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5417534/
https://ncbi.nlm.nih.gov/pubmed/20197308
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/me.2009-0391
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