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Runx2 Deficiency in Mice Causes Decreased Thyroglobulin Expression and Hypothyroidism
We recently reported on the overexpression of Runx2 (Cbfa1/AML3), an osteoblast-specific transcription factor, in human papillary thyroid cancer tissues. We report here that normal thyrocytes also express Runx2 and that Runx2(+/−) mice are in a hypothyroid state. To clarify the mechanism, we studied...
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| Publicat a: | Mol Endocrinol |
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| Autors principals: | , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Endocrine Society
2010
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5417472/ https://ncbi.nlm.nih.gov/pubmed/20375239 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/me.2010-0056 |
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